Are you familiar with the Vorkosigan saga? The main character, Miles Vorkosigan, was exposed to a toxin before he was born, and the result is that his bones are very brittle. I don't know if I can say it's accurate, since the toxin was made up and the effects were at the author's discretion, but with the caveat that I am a physically abled person and have no personal experience with the matter, I thought it was very well done.